Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633
Conclusion
Our findings demonstrate Pim1 as a novel kinase that is responsible for the phosphorylation of eNOS at Ser-633 and enhances EC sprouting of aortic rings from diabetic mice, suggesting that Pim1 could potentially serve as a novel therapeutic target for revascularization strategies.
Source: Cardiovascular Research - Category: Cardiology Authors: Chen, M., Yi, B., Zhu, N., Wei, X., Zhang, G.-X., Huang, S., Sun, J. Tags: Vascular Biology Source Type: research