Fallopian tube organoids promise better understanding of ovarian cancer, infertility

A new way of growing fallopian tube cells in culture is expected to give a boost to our understanding and prevention of female genital diseases, such as infertility, inflammatory disease, and ovarian cancer.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Amr Ahmed El-Arabey, Salama Abdu Salama, Adel Rashad Abd-AllahAbstractIn 2015, more than 1.6 million new cancer cases with 589,430 deaths were estimated over worldwide. Cancer is a complex disease with abnormal cell growth control which is hallmarked by chromosome misalignment and consequently genomic instability. Mitosis is a well-known target for chemotherapy as taxol and colchicines inhibit tumor cell division by inhibiting mitotic spindle plasticity. Accumulating evidence has revealed that the Centromere-associated protein E (CENP-E) is expr...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Mohammad Rasheduzzaman, Jae-Kyo Jeong, Sang-Youel ParkAbstractAimsTRAIL is a promising anticancer agent that has the potential to sensitize a wide variety of cancer or transformed cells by inducing apoptosis. However, resistance to TRAIL is a growing concern. Current manuscript aimed to employing combination treatment to investigate resveratrol induced TRAIL sensitization in NSCLC.MethodA549 and HCC-15 cells were used in experimental design. Cell viability was determined by morphological image, crystal violet staining and MTT assay. Apoptosis wa...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin, Shenming WangAbstractAimsBreast cancer is the major diagnosed cancer and the leading reason of cancer related death among women, and the tumor size is one of the risk factors. Therefore, it is significant to reveal the principle of breaking the subtle homeostasis of cell cycle and sustaining chronic proliferation of cancer cells.Main methodsThe expression of TNNT1 was examined by qPCR and western blotting. The effect of TNNT1 on cell proliferation was detected by...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: September 2018Source: Biomedical Signal Processing and Control, Volume 46Author(s): Supriya Patil, Gourish Naik, Radhakrishna Pai, Rajendra GadAbstractInvention of the microarray technology has rendered it possible to inspect the whole genome at once in cancer classification. However, in order to curtail the computational complexity and augment the accuracy of cancer classification, it is essential to sift the vast microarray data for the informative genes. In this paper, Thresholding and Ratio methods are presented, individually as well as conjointly (hybrid method) to choose optimal gene subset from the...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
We present a quantitative study of the performance of two automatic methods for the early detection of ovarian cancer that can exploit longitudinal measurements of multiple biomarkers. The study is carried out for a subset of the data collected in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). We use statistical analysis techniques, such as the area under the Receiver Operating Characteristic (ROC) curve, for evaluating the performance of two techniques that aim at the classification of subjects as either healthy or suffering from the disease using time-series of multiple biomarkers as inputs. The first ...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: Available online 18 July 2018Source: PeptidesAuthor(s): Sevil Arabaci Tamer, Alper Yildirim, M. Kutay köroğlu, Özge Çevik, Feriha Ercan, Berrak Ç. YeğenAbstractTesticular torsion causes ischemia-reperfusion injury and an increased risk of infertility. Nesfatin-1 is a novel peptide with antioxidant, anti-inflammatory and anti-apoptotic properties. In the present study, we aimed to investigate the putative beneficial effects of nesfatin-1 on oxidative injury and impaired testicular function induced by testis torsion. Under anesthesia, male Sprague-Dawley rats (180-230 g; n = ...
Source: Peptides - Category: Biochemistry Source Type: research
In conclusion, these results suggest the potential preventive effects of the five phytochemicals on the promoting effect of Ni on human lung cancer cell invasion. In addition, the preventive effects are associated with downregulation of the TLR4/NF-κB signaling pathway, especially for quercetin and chrysin.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Shuangshuang Wu, Changhui Chen, Haitang Yang, Wei Wei, Min Wei, Yuanjian Zhang, Songqin LiuAbstractPoly(ADP-ribose) polymerase-1 (PARP-1) monitoring has attracted extensive attention because it serves a vital role in human pathologies. However, only a few researches about its detection methods have been reported because PARP-1 and its catalyzed product poly(ADP-ribose) polymer (PAR) are lack of optical or electrochemical activity. Herein, a convenient fluorescence “turn-off-on” nanosensor based on cationic conjugat...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Conclusion Fimbrial cytobrushing using the transvaginal approach is an easy and minimally invasive procedure. The easy accessibility of the fimbrial end and the distal ampullary part at TVL allows an accurate collection of tubal epithelial cells. In view of the recent data reporting the Fallopian tube and more specifically the fimbrial end as a possible origin of ovarian carcinoma, further research is neede to evaluate the potential of this technique as a possible screening method for patients at risk for ovarian cancer.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
For SELF, by Zahra Barnes. A scary new report adds one more item to the “why women shouldn’t douche” list. Gynecologists have been telling their patients not to clean their vaginas with douches for years—and now they have yet another strong point against it: The practice is associated with nearly a doubled risk of getting ovarian cancer, according to a large study from the National Institute of Environmental Health Sciences. “Douching is just wrong,” Sherry Ross, M.D., an ob/gyn and women’s health expert at Providence Saint John’s Health Center in Santa M...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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