Fallopian tube organoids promise better understanding of ovarian cancer and infertility

(Max-Planck-Gesellschaft) A new way of growing Fallopian tube cells in culture is expected to give a boost to our understanding and prevention of female genital diseases, such as infertility, inflammatory disease, and ovarian cancer.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Publication date: Available online 23 February 2019Source: Advances in Biological RegulationAuthor(s): Alice Domenichini, Jeanne S. Edmands, Aleksandra Adamska, Romana-Rea Begicevic, Silvano Paternoster, Marco FalascaAbstractCancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attract interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the characteristi...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: Available online 22 February 2019Source: Carbohydrate PolymersAuthor(s): Elham Gholibegloo, Tohid Mortezazadeh, Fatemeh Salehian, Ali Ramazani, Massoud Amanlou, Mehdi KhoobiAbstractA novel β-cyclodextrin-based nanosponge (CDNS) was proposed as curcumin (CUR) delivery system improving pharmacokinetics and anticancer activity of CUR. The effect of molar ratio of Epiclon (EPI) as cross-linker and β-cyclodextrin (βCD) on the porosity, surface area, swelling ratio, CUR solubility and loading capacity, rate of drug release and selective toxicity of the CDNSs was fully investigated. The high degre...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 22 February 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Mojtaba Falahati, Farnoosh Attar, Majid Sharifi, Thomas Haertlé, Jean-François Berret, Rizwan Hasan Khan, Ali Akbar SabouryAbstractNanoparticle (NP)–protein complexes exhibit the “correct identity” of NP in biological media. Therefore, protein–NP interactions should be closely explored to understand and to modulate the nature of NPs in medical implementations. This review focuses mainly on the physicochemical parameters such as dimension, surface chemistry, the mo...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Publication date: 15 May 2019Source: Sensors and Actuators B: Chemical, Volume 287Author(s): Yongfei Huang, Yongbin Zhang, Fangjun Huo, Jianbin Chao, Caixia YinAbstractThe reactive oxygen species (ROS) including hypochlorous acid (HOCl), on the one hand they can regulate physiological function in our living organisms, on the other hand abnormal concentration of ROS would induce a series of biomacromolecules damage and further endanger virtually all aspects of human health. Especially it can be directly related to cancer. Thus to elucidate and visualize their concentration is very imminent. Before many fluorescent probes we...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Chandra Shekhar Pundir, Mansi Malik, Reeti ChaudharyAbstractPyruvate (carboxylate anion of pyruvic acid) is an organic molecule, with a backbone of 3‑carbon atoms. Pyruvate is known to undergo several fates depending upon the organism under consideration. It is one of the only molecules involved in both synthesis and breakdown pathways, thereby making it a very busy molecule. Aberrant levels of this metabolite are known to cause several disorders like diabetes, cirrhosis, cardiovascular diseases and severe brain abnormalities. This is an attrac...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Abstract Although cigarette smoking is a major risk factor for lung cancer, genetic susceptibility may also affect lung cancer risk. To explore the role of genetic risk, this case-control study investigated the association between family history of cancer at several sites and lung cancer risk. A total of 1,733 lung cancer cases and 6,643 controls were selected from patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009. Information on family history of cancer was collected using a self-administered questionnaire and odds ratios (ORs) were estimated by unconditional logistic re...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
I’m 37 and I have incurable bowel cancer. It’s spread to my liver and lungs. I was diagnosed three years ago, I have just an 8% chance of being alive in 2021.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 23 February 2019Source: European UrologyAuthor(s): Renate Pichler, Isabel Heidegger
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conclusion Fimbrial cytobrushing using the transvaginal approach is an easy and minimally invasive procedure. The easy accessibility of the fimbrial end and the distal ampullary part at TVL allows an accurate collection of tubal epithelial cells. In view of the recent data reporting the Fallopian tube and more specifically the fimbrial end as a possible origin of ovarian carcinoma, further research is neede to evaluate the potential of this technique as a possible screening method for patients at risk for ovarian cancer.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
For SELF, by Zahra Barnes. A scary new report adds one more item to the “why women shouldn’t douche” list. Gynecologists have been telling their patients not to clean their vaginas with douches for years—and now they have yet another strong point against it: The practice is associated with nearly a doubled risk of getting ovarian cancer, according to a large study from the National Institute of Environmental Health Sciences. “Douching is just wrong,” Sherry Ross, M.D., an ob/gyn and women’s health expert at Providence Saint John’s Health Center in Santa M...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
More News: Cancer | Cancer & Oncology | Fallopian Tube Cancer | Health | Infertility | International Medicine & Public Health | Ovarian Cancer | Ovaries | Reproduction Medicine