Metformin induced B12 deficiency

var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); Arch Int Med 2006 166: 1975-9Retrospective study found B12 deficiency correlated with dose and duration of metformin therapy.  B12 deficit defined as less than 150.  N was 155 patients.  Mechanism is inhibition of calcium dependent ileal absorption of B12-intrinsic factor,  which calcium supplementation can reverse.  Along with acid inhibitors (PPI's H2 blockers, metformin is most common cause of B12 deficiency.  Odds ratio is 2.88 for each i gram increment and 2.39 for use > 3 years.  In one study 6 percent of cases of B12 deficiency had associated metformin use (Br M J 1971) ,var pageTracker = _gat._getTracker("UA-3639768-12"); pageTracker._initData(); pageTracker._trackPageview();
Source: neurologyminutiae - Category: Neurologists Source Type: blogs