Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore

Conclusion
NAADP signalling plays a major role in reperfusion-induced cell death and represents a potent pathway for protection against reperfusion injury.

Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Davidson, S. M., Foote, K., Kunuthur, S., Gosain, R., Tan, N., Tyser, R., Zhao, Y. J., Graeff, R., Ganesan, A., Duchen, M. R., Patel, S., Yellon, D. M. Tags: Cardiac biology and remodelling Source Type: research