LSC Abstract - Regulation of regulatory T cell (Treg) function by cAMP-responsive element binding protein (CREB) and upstream microRNAs

Conclusion: The Creb/Crtc-pathway is activated in nTregs and in iTregs. Creb knockdown by siRNA or miR-17 & -21 reduced iTreg formation and might influence Treg function. A dysregulation of this pathway might contribute to chronic inflammatory diseases.

Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Bartel, S., Kästle, M., Noessner, E., Eickelberg, O., Krauss-Etschmann, S. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research