Development of Aortic Valve Disease in Familial Hypercholesterolemic Swine: Implications for Elucidating Disease Etiology [Valvular Heart Disease]

Conclusions
Adult RFH swine exhibited several hallmarks of early human CAVD, suggesting potential for these animals to help elucidate CAVD etiology in both FH and non-FH individuals. The development of advanced atherosclerotic lesions, but only early-stage CAVD, in RFH swine supports the hypothesis of an initial shared disease process, with additional stimulation necessary for further progression of CAVD.

Source: JAHA:Journal of the American Heart Association - October 27, 2015 Category: Cardiology Authors: Porras, A. M., Shanmuganayagam, D., Meudt, J. J., Krueger, C. G., Hacker, T. A., Rahko, P. S., Reed, J. D., Masters, K. S. Tags: Valvular Heart Disease Source Type: research