The neuroanatomy of pure apraxia of speech in stroke.

The neuroanatomy of pure apraxia of speech in stroke.
Brain Lang. 2014 Feb 17;129C:43-46
Authors: Graff-Radford J, Jones DT, Strand EA, Rabinstein AA, Duffy JR, Josephs KA
Abstract
The left insula or Broca's area have been proposed as the neuroanatomical correlate for apraxia of speech (AOS) based on studies of patients with both AOS and aphasia due to stroke. Studies of neurodegenerative AOS suggest the premotor area and the supplementary motor areas as the anatomical correlates. The study objective was to determine the common infarction area in patients with pure AOS due to stroke. Patients with AOS and no or equivocal aphasia due to ischemic stroke were identified through a pre-existing database. Seven subjects were identified. Five had pure AOS, and two had equivocal aphasia. MRI lesion analysis revealed maximal overlap spanning the left premotor and motor cortices. While both neurodegenerative AOS and stroke induced pure AOS involve the premotor cortex, further studies are needed to establish whether stroke-induced AOS and neurodegenerative AOS share a common anatomic substrate.
PMID: 24556336 [PubMed - as supplied by publisher]

Source: Brain and Language - February 17, 2014 Category: Neurology Authors: Graff-Radford J, Jones DT, Strand EA, Rabinstein AA, Duffy JR, Josephs KA Tags: Brain Lang Source Type: research