Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [ 11 C]MADAM PET study

Conclusions Escitalopram or citalopram doses nearly saturated SERT in previous monkey studies which examined serotonin sensitivity of receptor radioligands. PET-measured cross-species differential effects of SSRI on cortical serotonin concentration may thus be related to SSRI dose. Future monkey studies using SSRI doses inducing clinically relevant SERT occupancy may further illuminate the delayed onset of SSRI therapeutic effects.

http://link.springer.com/10.1007/s00213-015-3961-7

Source: Psychopharmacology - October 11, 2015 Category: Psychiatry Source Type: research