Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): impact of experimental conditions.

In conclusion, this study provides a detailed analysis of the CEES-induced PARylation response in HaCaT keratinocytes, which forms an experimental basis to study the molecular mechanism of PARP1 activation and its functional consequences after mustard treatment in general. Such a study is presented in an accompanying article (Mangerich/Debiak/Birtel et al., this issue). PMID: 26383632 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26383632?dopt=Abstract

Source: Toxicology Letters - September 14, 2015 Category: Toxicology Authors: Debiak M, Lex K, Ponath V, Burckhardt-Boer W, Thiermann H, Steinritz D, Schmidt A, Mangerich A, Bürkle A Tags: Toxicol Lett Source Type: research