Abstract CT317: Quantitative ultrasound for personalized chemotherapy in locally advanced breast cancer: Clinical trial results

This study investigated the potential to quantify tumour responses to therapy in patients, using quantitative spectral and textural biomarkers extracted from low-frequency ultrasound data (4-10 MHz). Results demonstrate for the first time in a large cohort of patients the ability to predict clinical responders from non-responders as early as one week after the start of chemotherapy with over 95% sensitivity and 95% specificity.A clinical study was undertaken investigating the efficacy of ultrasound to quantify cell death in tumor responses with cancer treatment. Patients (n = 100) with locally advanced breast cancer received anthracyline and taxane-based chemotherapy treatments over four to six months. Data collection consisted of acquiring tumor images and radiofrequency data prior to treatment onset and at 4 times during neoadjuvant chemotherapy (weeks 0, 1, 4, 8 and pre-operatively). Data collection was carried out using an Ultrasonix-RP and an L15-5 6cm transducer pulsed at frequencies of ∼5 and ∼7 MHz, respectively. The majority of patients went on to have a modified radical mastectomy and correlative whole mount histopathology.Results obtained from both ∼5 and ∼7 MHz data indicated considerable increases in ultrasound spectral backscatter power in patients who clinically responded to treatment within one week of starting their chemotherapy. This was accompanied by significant increases in quantitative ultrasound spectral parameters such as mid-band-fit (up to 9....
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Clinical Trials Source Type: research