External validation of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in an independent cohort.

CONCLUSION: Dmean and Vthyroid were significant predictors of RIHT in both cohorts. The original NTCP model demonstrated external validity owing to high Pearson's correlation coefficients between estimated and observed incidence rates of RIHT in the original as well as in the validation cohort. This model may facilitate clinically relevant estimations of RIHT after RT to the neck.
PMID: 26248025 [PubMed - as supplied by publisher]

Source: Acta Oncologica - August 6, 2015 Category: Cancer & Oncology Authors: Rønjom MF, Brink C, Bentzen SM, Hegedüs L, Overgaard J, Petersen JB, Primdahl H, Johansen J Tags: Acta Oncol Source Type: research