A Newborn with Congenital Mixed Phenotype Acute Leukemia After In Vitro Fertilization

Publication date: August 2015 Source:Pediatrics & Neonatology, Volume 56, Issue 4 Author(s): Hacer Ergin, Özmert M.A. Özdemir, Abdullah Karaca, Nilay Şen Türk, Füsun Düzcan, Şeniz Ergin, Elif Kazancı, Canan Vergin, Ayşe Erbay Congenital leukemia is a rare disease. The majority of cases of this disease are acute myelogenous leukemia (AML). Congenital acute lymphoblastic leukemia (ALL) is rare and most often is of B cell lineage. Rarely, some cases have been designated biphenotypic or mixed phenotype acute leukemia (MPAL). Herein, we report a preterm newborn referred to us as a result of the appearance of blue-violaceous dermal nodules on her body at birth. She was a twin and the product of an in vitro fertilization (IVF) pregnancy. Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules. Bone marrow aspiration showed 40% blasts of lymphoid lineage; skin biopsy and its immunohistochemistry revealed myeloblastic infiltration of the dermis. Cytogenetic analysis (46,XX), fluorescence in situ hybridization (FISH) analysis, and cranial magnetic resonance were normal. The patient was diagnosed with congenital MPAL, and an association between IVF and congenital leukemia was suggested.

Source: Pediatrics and Neonatology - July 31, 2015 Category: Perinatology & Neonatology Source Type: research