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There May Have Been a Major Breakthrough in MERS Treatment

Two existing and widely available drugs may prove to be effective treatments for Middle East Respiratory Syndrome (MERS), new research published by the University of Hong Kong suggests. According to the South China Morning Post, the medicines—lopinavir with ritonavir and a type of interferon—were tested on marmosets, small monkeys that a 2014 U.S. study concluded would be the best subject for MERS trials because of the way their reactions to the virus mimics human illness. The drugs, currently used to treat HIV and sclerosis, were found to be effective in curing MERS-infected marmosets. The research is the first of its kind in the world. “We would recommend doctors to start using both drugs immediately to treat MERS patients if they are critical,” said Jasper Chan Fuk-woo, one of the researchers, told SCMP. “The evidence in this study is quite strong in proving the effectiveness of these two drugs.” Currently, there is no known cure for MERS. Meanwhile, South Korea, which struggled with a MERS outbreak in May and June, has not reported any new MERS cases for 23 days and no deaths for more than two weeks. The country declared a “de-facto end” to its outbreak on July 28, although a spokesman for the World Health Organization told the BBC it would not declare an official end to the country’s outbreak until 28 days had passed with no new infections—twice the disease’s incubation period. [SCMP]
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Hong Kong medicine MERS monkeys Science South Korea Source Type: news

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Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data have not been utilised to their full potential. Here we use existing MERS-CoV sequence data to explore its phylodynamics in two of its known major hosts, humans and camels. We employ structured coalescent models to show that long-term MERS-CoV evolution occurs exclusively in ...
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Genomics and Evolutionary Biology Source Type: research
(MedPage Today) -- News and commentary from the world of infectious diseases
Source: MedPage Today Public Health - Category: American Health Source Type: news
Disease News Outbreak on Middle East coronavirus (MERS-CoV) in Malaysia.
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e.g., the severe acute respiratory syndrome (SARS) virus, the Middle East respiratory sy...
Source: ASAIO Journal - Category: Medical Devices Tags: Review Article Source Type: research
Publication date: Available online 28 December 2017 Source:Antiviral Research Author(s): Min-Han Lin, David C. Moses, Chih-Hua Hsieh, Shu-Chun Cheng, Yau-Hung Chen, Chiao-Yin Sun, Chi-Yuan Chou Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in southern China in late 2002 and caused a global outbreak with a fatality rate around 10% in 2003. Ten years later, a second highly pathogenic human CoV, MERS-CoV, emerged in the Middle East and has spread to other countries in Europe, North Africa, North America and Asia. As of November 2017, MERS-CoV had infected at least 2102 people with a fatality rate of about ...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in southern China in late 2002 and caused a global outbreak with a fatality rate around 10% in 2003. Ten years later, a second highly pathogenic human CoV, MERS-CoV, emerged in the Middle East and has spread to other countries in Europe, North Africa, North America and Asia. As of November 2017, MERS-CoV had infected at least 2102 people with a fatality rate of about 35% globally, and hence there is an urgent need to identify antiviral drugs that are active against MERS-CoV. Here we show that a clinically available alcohol-aversive drug, dis...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
On 11 December 2017, the National IHR Focal Point of the United Arab Emirates (UAE) reported one additional case of Middle East Respiratory Syndrome (MERS-CoV) infection. Detailed information concerning the case reported, a 39-year-old male residing in Hemma Region, Oman can be found in a separate document (see link below). The case is currently asymptomatic, is in home isolation in Oman, and is being monitored for the development of symptoms. 


Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e.g., the severe acute respiratory syndrome (SARS) virus, the Middle East respiratory sy...
Source: ASAIO Journal - Category: Medical Devices Tags: Review Article Source Type: research
Disease outbreak news for MERS-CoV in Saudi Arabia
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Conclusion: The adoption of CERC principles can help restore and maintain the credibility of responding agencies. Further work is needed to develop more rigorous and comprehensive research strategies that address sharing of information by mainstream as well as social media for a more accurate assessment of the impact of the ERC strategy.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Case Report Source Type: research
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