There May Have Been a Major Breakthrough in MERS Treatment
Two existing and widely available drugs may prove to be effective treatments for Middle East Respiratory Syndrome (MERS), new research published by the University of Hong Kong suggests. According to the South China Morning Post, the medicines—lopinavir with ritonavir and a type of interferon—were tested on marmosets, small monkeys that a 2014 U.S. study concluded would be the best subject for MERS trials because of the way their reactions to the virus mimics human illness. The drugs, currently used to treat HIV and sclerosis, were found to be effective in curing MERS-infected marmosets. The research is the first of its kind in the world. “We would recommend doctors to start using both drugs immediately to treat MERS patients if they are critical,” said Jasper Chan Fuk-woo, one of the researchers, told SCMP. “The evidence in this study is quite strong in proving the effectiveness of these two drugs.” Currently, there is no known cure for MERS. Meanwhile, South Korea, which struggled with a MERS outbreak in May and June, has not reported any new MERS cases for 23 days and no deaths for more than two weeks. The country declared a “de-facto end” to its outbreak on July 28, although a spokesman for the World Health Organization told the BBC it would not declare an official end to the country’s outbreak until 28 days had passed with no new infections—twice the disease’s incubation period. [SCMP]
(KDKA/CBS Local) – Researchers say they have identified a new pig virus that could be a threat to humans. The virus was found to easily make its way into laboratory-cultured cells of humans and other species, a discovery that raises concerns about potential outbreaks in people. Researchers at The Ohio State University and Utrecht University in the Netherlands collaborated to better understand the new virus identified as porcine deltacoronavirus. Their study appears online in the journal PNAS. Scientists say the virus was first discovered in pigs in China in 2012. It was first detected in the United States in 201...
Conclusions This hospital outbreak demonstrated the difficulties in diagnosing pneumonia in patients with renal and cardiac failure, which leads to delayed suspicion of MERS-CoV and hence delay in applying the proper infection control procedures. In MERS-CoV endemic countries there is an urgent need for developing rapid point-of-care testing that would assist emergency department staff in triaging suspected cases of MERS-CoV to ensure timely isolation and management of their primary illness and prevent major MERS-CoV outbreaks.
ConclusionPVP-I 7% gargle/mouthwash showed rapid bactericidal activity and virucidal efficacy in vitro at a concentration of 0.23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens.FundingMundipharma Research GmbH&Co. KG (MRG).
Conclusion: Our findings indicate that the acute treatment of MERS-CoV infections in quarantine had a significant impact on the patients' mental health. Furthermore, assessment of the risk factors for depression may identify vulnerable patients who require psychiatric care and attention during hospital quarantine. PMID: 29593206 [PubMed - as supplied by publisher]
Conclusions Although a considerable number of HCP experienced MERS-related symptoms or unprotected exposure during MERS patient care, some did not take appropriate action. These findings imply that for infection control strategy to be properly performed, education should be strengthened so that HCP can accurately recognize the risk situation and properly notify the infection control officer.
Disease news outbreak for MERS_CoV in Oman.
Conclusions It is necessary to examine the difficulties and demands of healthcare providers for establishing a safe healthcare system to respond effectively when national disasters occur. In addition, it is necessary to develop strategies to protect healthcare providers from severe physical and psychological stress.
CONCLUSION: As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections. PMID: 29402475 [PubMed - as supplied by publisher]
Between 9 December 2017 and 17 January 2018, the National IHR Focal Point of The Kingdom of Saudi Arabia reported 20 additional cases of Middle East Respiratory Syndrome (MERS), including eight deaths. In addition, one death from a previously reported case was reported to WHO.
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data have not been utilised to their full potential. Here we use existing MERS-CoV sequence data to explore its phylodynamics in two of its known major hosts, humans and camels. We employ structured coalescent models to show that long-term MERS-CoV evolution occurs exclusively in ...