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There May Have Been a Major Breakthrough in MERS Treatment

Two existing and widely available drugs may prove to be effective treatments for Middle East Respiratory Syndrome (MERS), new research published by the University of Hong Kong suggests. According to the South China Morning Post, the medicines—lopinavir with ritonavir and a type of interferon—were tested on marmosets, small monkeys that a 2014 U.S. study concluded would be the best subject for MERS trials because of the way their reactions to the virus mimics human illness. The drugs, currently used to treat HIV and sclerosis, were found to be effective in curing MERS-infected marmosets. The research is the first of its kind in the world. “We would recommend doctors to start using both drugs immediately to treat MERS patients if they are critical,” said Jasper Chan Fuk-woo, one of the researchers, told SCMP. “The evidence in this study is quite strong in proving the effectiveness of these two drugs.” Currently, there is no known cure for MERS. Meanwhile, South Korea, which struggled with a MERS outbreak in May and June, has not reported any new MERS cases for 23 days and no deaths for more than two weeks. The country declared a “de-facto end” to its outbreak on July 28, although a spokesman for the World Health Organization told the BBC it would not declare an official end to the country’s outbreak until 28 days had passed with no new infections—twice the disease’s incubation period. [SCMP]
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Hong Kong medicine MERS monkeys Science South Korea Source Type: news

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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Local TV talkers Source Type: news
Conclusions This hospital outbreak demonstrated the difficulties in diagnosing pneumonia in patients with renal and cardiac failure, which leads to delayed suspicion of MERS-CoV and hence delay in applying the proper infection control procedures. In MERS-CoV endemic countries there is an urgent need for developing rapid point-of-care testing that would assist emergency department staff in triaging suspected cases of MERS-CoV to ensure timely isolation and management of their primary illness and prevent major MERS-CoV outbreaks.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
ConclusionPVP-I 7% gargle/mouthwash showed rapid bactericidal activity and virucidal efficacy in vitro at a concentration of 0.23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens.FundingMundipharma Research GmbH&Co. KG (MRG).
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Conclusion: Our findings indicate that the acute treatment of MERS-CoV infections in quarantine had a significant impact on the patients' mental health. Furthermore, assessment of the risk factors for depression may identify vulnerable patients who require psychiatric care and attention during hospital quarantine. PMID: 29593206 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Conclusions Although a considerable number of HCP experienced MERS-related symptoms or unprotected exposure during MERS patient care, some did not take appropriate action. These findings imply that for infection control strategy to be properly performed, education should be strengthened so that HCP can accurately recognize the risk situation and properly notify the infection control officer.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Disease news outbreak for MERS_CoV in Oman.
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Conclusions It is necessary to examine the difficulties and demands of healthcare providers for establishing a safe healthcare system to respond effectively when national disasters occur. In addition, it is necessary to develop strategies to protect healthcare providers from severe physical and psychological stress.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
CONCLUSION: As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections. PMID: 29402475 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Between 9 December 2017 and 17 January 2018, the National IHR Focal Point of The Kingdom of Saudi Arabia reported 20 additional cases of Middle East Respiratory Syndrome (MERS), including eight deaths. In addition, one death from a previously reported case was reported to WHO.
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data have not been utilised to their full potential. Here we use existing MERS-CoV sequence data to explore its phylodynamics in two of its known major hosts, humans and camels. We employ structured coalescent models to show that long-term MERS-CoV evolution occurs exclusively in ...
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Genomics and Evolutionary Biology Source Type: research
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