Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil ( Ocimum basilicum L.) leaves

This study investigated the biological activities of essential oil from sweet basil leaves via its effect on α-amylase, α-glucosidase and angiotensin-I-converting enzyme (ACE) activities, inhibition of Fe2+ and sodium nitroprusside (SNP)-induced lipid peroxidation in rats’ pancreas and heart homogenates. The phytoconstituents of the oil were analysed using gas chromatography (GC). The essential oil exhibited a dose-dependent inhibition of α-amylase (IC50 = 3.21 mg/mL), α-glucosidase (IC50 = 3.06 mg/mL) and ACE (IC50 = 0.89 mg/mL) activities in vitro. The oil also inhibited both Fe2+- and SNP-induced lipid peroxidation in rats’ pancreas and heart. The GC analysis revealed the presence of about 28 phytoconstituents, with limonene (47.40 %), borneol (8.66 %), geranial (6.93 %), neral (5.71 %), myrcene (4.68 %), β-caryophyllene (4.68 %), α-terpineol (4.60 %), 1,8-cineole (4.17 %), linalool (3.53 %), β-elemene (3.05 %), germacrene D (2.68 %), and terpinen-4-ol (2.21 %) being the most prominent. Thus, the antioxidant and enzyme inhibitory effects of the essential oil could be attributed to the presence of these phytochemicals, which could be the principle responsible for the antidiabetic and antihypertensive properties of the essential oil. This study therefore, could provide the possible rationale for the applicati...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
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Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
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Source: The International Journal of Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Int J Biochem Cell Biol Source Type: research
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Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
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