Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice

ConclusionsLB impairs the capacity of reelin-positive cells located in the LEC to project and innervate the dorsal hippocampus in LB males but not female LB littermates. Given the critical role that these projections play in supporting normal hippocampal function, a failure to establish proper connectivity between the LEC and the dorsal hippocampus provides a compelling and novel mechanism to explain the more severe deficits in myelination and contextual freezing found in adolescent LB males.

Source: Biology of Sex Differences - May 7, 2024 Category: Biology Source Type: research