GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats

In conclusion, this study provided evidence that the loss of GABAergic interneuron phenotype in CA1 may contribute to contextual fear generalization in PTSD. The PERK pathway is involved in the GABAergic interneuron injury of PTSD rats and modulating it can protect GABAergic interneurons and constrain contextual fear generalization.

https://onlinelibrary.wiley.com/doi/10.1111/jnc.16123?af=R

Source: Journal of Neurochemistry - May 6, 2024 Category: Neuroscience Authors: Xiayu Gong, Zhixin Fan, Hanfang Xu, Yue Qu, Bozhi Li, Lanxin Li, Yuqi Yan, Lili Wu, Can Yan Tags: ORIGINAL ARTICLE Source Type: research