The burden of skull base chordomas: insights from a meta-analysis of observational studies

CONCLUSIONS: The results of this comprehensive meta-analysis highlight the tremendous impact of GTR and adjuvant PBRT on improving OS and PFS of patients harboring skull base chordomas, with better survival rates demonstrated for patients with chondroid tumors. Even in experienced hands, the rate of surgical morbidity remains high. Proper management in high-volume centers is mandatory to reach the expected resection goal at the first surgical attempt and to reduce surgical morbidity. The introduction of the endoscopic endonasal approach was related to improved surgical and functional outcomes.PMID:38691853 | DOI:10.3171/2024.3.FOCUS23922
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Source Type: research