Intensive Re-Induction Chemotherapy Followed by Early Allogeneic Hematopoietic Cell Transplant for Relapsed/Refractory High-Grade Myeloid Neoplasms

Despite recent advances in systemic therapy, most patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) and other high-grade myeloid neoplasms continue to have poor outcomes, with allogeneic hematopoietic cell transplantation (HCT) remaining the only curative option.1 Since few adults transplanted with active disease survive long-term, salvage chemotherapy is typically given first to induce a complete remission (CR;

Source: Biology of Blood and Marrow Transplantation - May 4, 2024 Category: Hematology Authors: Noam E. Kopmar, Megan Othus, Kim Quach, Allegra Rasmussen, Kelda Schonhoff, Pamela S. Becker, Roland B. Walter, Anna B. Halpern, Rachel Salit, Ryan D. Cassaday, Andrei Shustov, F. Marc Stewart, Vivian G. Oehler, Bart L. Scott, Brenda M. Sandmaier, Stephan Source Type: research