Viruses, Vol. 16, Pages 722: Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome

Viruses, Vol. 16, Pages 722: Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome Viruses doi: 10.3390/v16050722 Authors: Karakoz Mussabay Samat Kozhakhmetov Marat Dusmagambetov Aitolkyn Mynzhanova Madiyar Nurgaziyev Zharkyn Jarmukhanov Elizaveta Vinogradova Aigul Dusmagambetova Aiganym Daulbaeva Laura Chulenbayeva Ainur Tauekelova Makhabbat Bekbossynova Almagul Kushugulova Recent studies highlight the crucial role of the gut microbiome in post-infectious complications, especially in patients recovering from severe COVID-19. Our research aimed to explore the connection between gut microbiome changes and the cytokine profile of patients with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed the composition of the gut microbiome in 60 COVID-19 patients over the course of one year. We also measured the levels of serum cytokines and chemokines using the Milliplex system. Our results showed that severe SARS-CoV-2 infection cases, especially those complicated by pneumonia, induce a pro-inflammatory microbial milieu with heightened presence of Bacteroides, Faecalibacterium, and Prevotella_9. Furthermore, we found that post-COVID syndrome is characterized by a cross-correlation of various cytokines and chemokines MDC, IL-1b, Fractalkine, TNFa, FGF-2, EGF, IL-1RA, IFN-a2, IL-10, sCD40L, IL-8, Eotaxin, IL-12p40, and MIP-1b as well as a shift in the gut microbiome towards a pro-inflammatory profile. At the functional level, our a...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research