Viruses, Vol. 16, Pages 722: Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome
Viruses, Vol. 16, Pages 722: Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome
Viruses doi: 10.3390/v16050722
Authors:
Karakoz Mussabay
Samat Kozhakhmetov
Marat Dusmagambetov
Aitolkyn Mynzhanova
Madiyar Nurgaziyev
Zharkyn Jarmukhanov
Elizaveta Vinogradova
Aigul Dusmagambetova
Aiganym Daulbaeva
Laura Chulenbayeva
Ainur Tauekelova
Makhabbat Bekbossynova
Almagul Kushugulova
Recent studies highlight the crucial role of the gut microbiome in post-infectious complications, especially in patients recovering from severe COVID-19. Our research aimed to explore the connection between gut microbiome changes and the cytokine profile of patients with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed the composition of the gut microbiome in 60 COVID-19 patients over the course of one year. We also measured the levels of serum cytokines and chemokines using the Milliplex system. Our results showed that severe SARS-CoV-2 infection cases, especially those complicated by pneumonia, induce a pro-inflammatory microbial milieu with heightened presence of Bacteroides, Faecalibacterium, and Prevotella_9. Furthermore, we found that post-COVID syndrome is characterized by a cross-correlation of various cytokines and chemokines MDC, IL-1b, Fractalkine, TNFa, FGF-2, EGF, IL-1RA, IFN-a2, IL-10, sCD40L, IL-8, Eotaxin, IL-12p40, and MIP-1b as well as a shift in the gut microbiome towards a pro-inflammatory profile. At the functional level, our a...
Source: Viruses - Category: Virology Authors: Karakoz Mussabay Samat Kozhakhmetov Marat Dusmagambetov Aitolkyn Mynzhanova Madiyar Nurgaziyev Zharkyn Jarmukhanov Elizaveta Vinogradova Aigul Dusmagambetova Aiganym Daulbaeva Laura Chulenbayeva Ainur Tauekelova Makhabbat Bekbossynova Almagul Kushugulova Tags: Article Source Type: research