Cancers, Vol. 16, Pages 1753: The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care

Cancers, Vol. 16, Pages 1753: The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care Cancers doi: 10.3390/cancers16091753 Authors: S. Joy Trybula Mark W. Youngblood Constantine L. Karras Nikhil K. Murthy Amy B. Heimberger Rimas V. Lukas Sean Sachdev John A. Kalapurakal James P. Chandler Daniel J. Brat Craig M. Horbinski Stephen T. Magill Meningioma classification and treatment have evolved over the past eight decades. Since Bailey, Cushing, and Eisenhart’s description of meningiomas in the 1920s and 1930s, there have been continual advances in clinical stratification by histopathology, radiography and, most recently, molecular profiling, to improve prognostication and predict response to therapy. Precise and accurate classification is essential to optimizing management for patients with meningioma, which involves surveillance imaging, surgery, primary or adjuvant radiotherapy, and consideration for clinical trials. Currently, the World Health Organization (WHO) grade, extent of resection (EOR), and patient characteristics are used to guide management. While these have demonstrated reliability, a substantial number of seemingly benign lesions recur, suggesting opportunities for improvement of risk stratification. Furthermore, the role of adjuvant radiotherapy for grade 1 and 2 meningioma remains controversial. Over the last decade, numerous studies investigating the molecular drivers o...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research