Association between arachidonate lipoxygenase 15,c.-292  C  & gt;  T gene polymorphism and non-cystic fibrosis bronchiectasis in children: a pilot study on the effects on airway lipoxin A4 and disease phenotype

ConclusionsLow airway LXA4 in children with NCFB is associated with severe disease phenotype and lung function deterioration.CTgenotype ofALOX-15,c.-292 C> Tpolymorphism might be a protective genetic factor against bronchiectasis development and/or progression due to enhanced LXA4 production.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research