NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension

CONCLUSIONS: These observations identify a role of NETosis in the pathogenesis of hypertension. Moreover, they define an important role of EC stretch and TRPV4 as initiators of NETosis. Finally, they define a role of citrullinated histones as drivers of EC dysfunction in hypertension.PMID:38666386 | DOI:10.1161/CIRCRESAHA.123.323897

Source: Circulation Research - April 26, 2024 Category: Cardiology Authors: Jaya Krishnan Elizabeth M Hennen Mingfang Ao Annet Kirabo Taseer Ahmad N éstor de la Visitación David M Patrick Source Type: research