Genes, Vol. 15, Pages 565: Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex

Genes, Vol. 15, Pages 565: Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex Genes doi: 10.3390/genes15050565 Authors: Kirsten Voorhies Julian Hecker Sanghun Lee Georg Hahn Dmitry Prokopenko Merry-Lynn McDonald Alexander C. Wu Ann Wu John E. Hokanson Michael H. Cho Christoph Lange Karin F. Hoth Sharon M. Lutz Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In order to examine the association of SNPs with depression and smoking in the UK Biobank with replication in the COPDGene study, we used counterfactual-based mediation analysis to test the indirect or mediated effect of SNPs on broad depression through the log of pack-years of cigarette smoking, adjusting for age, sex, current smoking status, and genetic ancestry (via principal components). In secondary analyses, we adjusted for age, sex, current smoking status, genetic ancestry (via principal components), income, education, and living status (urban vs. rural). In addition, we examined sex-stratified mediation models and sex-moderated mediation models. For both analyses, we adjusted for age, current smoking status, and genetic ancestry (via principal components). In the UK Biobank, rs6424532 [LOC105378800] had a statistically significant indirect effect on broad depress...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Brief Report Source Type: research