Viral remodeling of the 4D nucleome

Experimental & Molecular Medicine, Published online: 25 April 2024; doi:10.1038/s12276-024-01207-0This research examines how viruses can change the 3D structure of host DNA, focusing on the role of CTCF and cohesin proteins in altering both viral and cellular 3D DNA structures. The scientists used various techniques, including chromosome conformation capture and next-generation sequencing, to study the 3D structure of both viral and cellular genomes. They discovered that viral infections can cause changes in gene loop formation, chromatin accessibility, and shifts in genome compartments. These changes can affect gene activity and various biological processes, potentially leading to diseases like cancer. The research concludes that understanding the spatial and temporal aspects of viral infection is vital for a full understanding of virus biology and the cellular 4D nucleome. This could lead to new treatment opportunities to fight virus infection, persistence, and disease development. “This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author”.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research