Effects of oral administration of ondansetron, a 5-HT < sub > 3 < /sub > receptor antagonist, on anxiety-related behaviors and colonic hypercontractility in repeated stress-induced mice

CONCLUSIONS: Oral administration of ondansetron prevented increased FPO but did not affect anxiety-related behavior in repeated stress model. Colonic hypercontractility in the stressed mice was related to increased responses to cholinergic-induced contractions, which involved 5-HT3 receptors. Our findings suggest the modulatory roles of 5-HT3 receptors to mediate stress-induced colonic dysfunction.PMID:38642511 | DOI:10.1016/j.autneu.2024.103178

Source: Autonomic Neuroscience - April 20, 2024 Category: Neuroscience Authors: Affan Waemong Sarunnuch Sattayachiti Dania Cheaha Nipaporn Konthapakdee Source Type: research