TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma

CONCLUSION: Sarcomatoid and rhabdoid BUC do harbor positive expression of the ADC targets TROP-2 or NECTIN-4 in a relatively modest subset of cases, whereas the majority do not. Different combinations of other positive biomarkers may help the choice of medical therapies. Overall, these findings have important clinical implications for targeted therapy for BUC.PMID:38482675 | PMC:PMC10938277 | DOI:10.32074/1591-951X-937

Source: Pathologica - March 14, 2024 Category: Pathology Authors: Matteo Brunelli Stefano Gobbo Giorgio Malpeli Grazia Sirgiovanni Claudia Caserta Enrico Munari Simona Francesconi Anna Cali ò Guido Martignoni Alessia Cimadamore Alessandro Veccia Alessandro Antonelli Marcello Tucci Francesco Pierconti Isabelle Malak Hat Source Type: research