The application of umbilical cord blood-derived platelet gel for skin ulcers associated with chronic graft-versus-host disease in pediatrics: A randomized trial

Hematopoietic stem cell transplantation (HSCT) is a definitive therapy for a myriad of malignant and non-malignant hematopoietic, immune-related, and lysosomal storage disorders1, 2. However, graft-versus-host disease (GVHD), the main complication of allogeneic HSCT (allo-HSCT), significantly compromises the survival and the quality of life of recipients3-5. Accordingly, chronic GVHD (cGVHD) afflicts 20-50% of allo-HSCT cases6 and is one of the principal etiologies of morbidity and compromised quality of life, especially among pediatric patients7, 8.

Source: Biology of Blood and Marrow Transplantation - April 23, 2024 Category: Hematology Authors: Rashin Mohseni, Pouya Mahdavi Sharif, Abbas Khosravi, Ahmad Reza Taheri, Maryam Behfar, Morteza Zarrabi, Leila Jafari, Fahimeh Jafari, Zeynab Nikfetrat, Parisa Naji, Amir Ali Hamidieh Source Type: research