Custom ‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

The fundamental design principles governing the use of degradable silica nanoparticles, particularly their responsiveness to endogenous/exogenous stimuli, are meticulously outlined in this review, which delves into the use of these nanoparticles for the integration of chemotherapy and diverse treatment modalities. Additionally, this review highlights potential challenges that may impede future research progress and the translation of these innovative approaches into clinical applications. AbstractChemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles in tumor diagnosis and treatment lie in their ability to target drug delivery, minimizing toxicity to normal tissues while enhancing therapeutic efficacy. Moreover, their responsiveness to both endogenous and exogenous stimuli opens up new possibilities for integrating multiple treatment modalities. This review scrutinizes the burgeoning utility of degradable silica nanoparticles in combination with chemotherapy and other treatment modalities. Commencing the elucidation of degradable silica synthesis and degradation mechanisms, emphasis is placed on the responsiveness of these materials to endogenous (e.g., pH, redox reactions, hypoxia, and enzymes) and exogenous stimuli (e.g., light and high-intensity focused ultrasound). Moreover, this exploration delves into ...
Source: Small - Category: Nanotechnology Authors: Tags: Review Source Type: research