ZFP36L1 controls KLF16 mRNA stability in vascular smooth muscle cells during restenosis after vascular injury

This study aimed to evaluate the role of ZFP36L1 in restenosis. We found that the expression of ZFP36L1 was inhibited in VSMC-phenotypic transformation induced by TGF- β, PDGF-BB, and FBS and also in the rat carotid injury model. In addition, we found that the overexpression of ZFP36L1 inhibited the proliferation and migration of VSMCs and promoted the expression of VSMC contractile genes; whereas ZFP36L1 interference promoted the proliferation and migration of V SMCs and suppressed the expression of contractile genes.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research