Endothelial Cell Flow-Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27

CONCLUSIONS: Endothelial cell flow-mediated quiescence has unique properties and temporal regulation of quiescence depth that depends on the flow stimulus. These findings are consistent with a model whereby flow-mediated endothelial cell quiescence depth is temporally regulated downstream of p27 transcriptional regulation by HES1 and ID3. The findings are important in understanding endothelial cell quiescence misregulation that leads to vascular dysfunction and disease.PMID:38602102 | DOI:10.1161/ATVBAHA.124.320671

Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 11, 2024 Category: Cardiology Authors: Natalie T Tanke Ziqing Liu Michaelanthony T Gore Pauline Bougaran Mary B Linares Allison Marvin Arya Sharma Morgan Oatley Tianji Yu Kaitlyn Quigley Sarah Vest Jeanette Gowen Cook Victoria L Bautch Source Type: research