Ticagrelor downregulates the expression of proatherogenic and proinflammatory miR125-b compared to clopidogrel: A randomized, controlled trial
Platelet P2Y12 antagonist ticagrelor reduces cardiovascular mortality after acute myocardial infarction (AMI) compared to clopidogrel, but the underlying mechanism is unknown. Because activated platelets release proatherogenic and proinflammatory microRNAs, including miR-125a, miR-125b and miR-223, we hypothesized that the expression of these miRNAs is lower on ticagrelor, compared to clopidogrel.
Source: International Journal of Cardiology - Category: Cardiology Authors: Aleksandra Gasecka, Ewelina B łażejowska, Kinga Pluta, Magdalena Gajewska, Sylwester Rogula, Krzysztof J. Filipiak, Janusz Kochman, Jolanta M. Siller-Matula, Marek Postuła, Ceren Eyileten Source Type: research