Cancers, Vol. 16, Pages 1563: Latest Insights and Therapeutic Advances in Myelodysplastic Neoplasms

Cancers, Vol. 16, Pages 1563: Latest Insights and Therapeutic Advances in Myelodysplastic Neoplasms Cancers doi: 10.3390/cancers16081563 Authors: Pasquale Niscola Valentina Gianfelici Marco Giovannini Daniela Piccioni Carla Mazzone Paolo de Fabritiis Myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the hematopoietic stem cell compartment drive disease pathogenesis. Recent advancements in genomic profiling have provided valuable insights into the biological underpinnings of MDSs and have expanded therapeutic options, particularly for specific molecularly defined subgroups. This review highlights the diagnostic principles, classification updates, prognostic stratification systems, and novel treatments, which could inform future clinical trials and enhance the management of adult MDS patients, particularly for specific molecularly defined subgroups.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research