Cancers, Vol. 16, Pages 1574: The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience

Cancers, Vol. 16, Pages 1574: The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience Cancers doi: 10.3390/cancers16081574 Authors: Fabio Cofano Andrea Bianconi Raffaele De Marco Elena Consoli Pietro Zeppa Francesco Bruno Alessia Pellerino Flavio Panico Luca Francesco Salvati Francesca Rizzo Alberto Morello Roberta Rudà Giovanni Morana Antonio Melcarne Diego Garbossa Given the importance of maximizing resection for prognosis in patients with HGG and the potential risks associated with ventricle opening, this study aimed to assess the actual increase in post-surgical complications related to lateral ventricle opening and its influence on OS and PFS. A retrospective study was conducted on newly diagnosed HGG, dividing the patients into two groups according to whether the lateral ventricle was opened (69 patients) or not opened (311 patients). PFS, OS, subependymal dissemination, distant parenchymal recurrences, the development of hydrocephalus and CSF leak were considered outcome measures. A cohort of 380 patients (154 females (40.5%) and 226 males (59.5%)) was involved in the study (median age 61 years). The PFS averaged 10.9 months (±13.3 SD), and OS averaged 16.6 months (± 16.3 SD). Among complications, subependymal dissemination was registered in 15 cases (3.9%), multifocal and multicentric progression in 56 cases (14.7%), leptomeningeal di...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research