The proprotein convertase FURIN is a novel aneurysm predisposition gene impairing TGF- β signaling

CONCLUSION: FURIN is a novel, frequent genetic predisposition for abdominal-, thoracic-, and multiple aortic or middle sized artery aneurysms in older patients, by affecting intracellular TGF-β signaling, depending on individual genetic backgrounds.PMID:38636100 | DOI:10.1093/cvr/cvae078

Source: Cell Research - April 18, 2024 Category: Cytology Authors: Zongsheng He Arne S IJpma Dianne Vreeken Daphne Heijsman Karen Rosier Hence J M Verhagen Jorg de Bruin Hennie T Br üggenwirth Jolien W Roos-Hesselink Jos A Bekkers Danny Huylebroeck Heleen van Beusekom John W M Creemers Danielle Majoor-Krakauer Source Type: research