The coupling between healthspan and lifespan in < em > Caenorhabditis < /em > depends on complex interactions between compound intervention and genetic background

In this study, thermotolerance, but not oxidative stress or swimming ability, correlates with lifespan. Notably, some compounds exert strong impact on some health measures without an equally strong impact on lifespan. Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible anti-aging interventions, with data underscoring how personalized treatments might be required to optimize health benefits.PMID:38613792 | DOI:10.18632/aging.205743

Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Stephen A Banse E Grace Jackson Christine A Sedore Brian Onken David Hall Anna Coleman-Hulbert Phu Huynh Theo Garrett Erik Johnson Girish Harinath Delaney Inman Suzhen Guo Mackenzie Morshead Jian Xue Ron Falkowski Esteban Chen Christopher Herrera Allie J Source Type: research