Optimal Method for Assessing Right Ventricular to Pulmonary Arterial Coupling and Subclinical Right Ventricular Dysfunction in Older Aged Healthy Adults: The Multi-Ethnic Study of Atherosclerosis.

The ability of the right ventricle (RV) to adapt to increasing afterload, particularly in diseases such as pulmonary arterial hypertension (PAH)1, is a primary determinant of morbidity and mortality. In the early stages of pulmonary hypertension (PH), cardiac output is maintained through compensatory hypertrophy of the RV chamber to enhance contractility. However, with sustained pressure overload, these maladaptive compensatory mechanisms are insufficient, and the chamber begins to dilate to maintain cardiac output, known as uncoupling of the RV to pulmonary artery (PA) and the onset of clinical heart failure (HF)2,3.

Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Vivek P. Jani, Jordan B. Strom, Abhishek Gami, Lauren Beussink-Nelson, Ravi Patel, Erin D. Michos, Sanjiv J. Shah, Benjamin H. Freed, Monica Mukherjee Source Type: research