Early heart and skeletal muscle mitochondrial response to a moderate hypobaric hypoxia environment
In conclusion, mitochondria from the muscle and heart respond differently to MHH: mitochondrial supercomplexes increase in the heart, whereas, in skeletal muscle, the mitochondrial pro-fission response is trigged. Considering that skeletal muscle was not actively involved in the ascent when the heart was beating faster to compensate for the hypobaric, hypoxic conditions, we speculate that the different responses to MHH are a result of the different energetic requirements of the tissues upon MHH. KEY POINTS: The heart and the skeletal muscle showed different mitochondrial responses to moderate hypobaric hypoxia. Moderate hypobaric hypoxia increases the assembly of the electron transport chain complexes into supercomplexes in the heart. Skeletal muscle shows an early mitochondrial pro-fission response following exposure to moderate hypobaric hypoxia.PMID:38630964 | DOI:10.1113/JP285516
Source: The Journal of Physiology - Category: Physiology Authors: Jer ónimo Aragón-Vela Rafael A Casuso Ana Sagrera Aparisi Julio Plaza-D íaz Ascensi ón Rueda-Robles Agust ín Hidalgo-Gutiérrez Luis Carlos L ópez Andrea Rodr íguez-Carrillo Jos é Antonio Enriquez Sara Cogliati Jes ús R Huertas Source Type: research
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