Genomic characterisation of clinically significant blood group variants in Aboriginal Australians

In this study, we applied next-generation sequencing and analysis to 245 samples obtained from Aboriginal Australians from South-East Queensland, to predict antigen phenotypes for 36 blood group systems.RESULTS: We report potential weak antigens in blood group systems RH, FY and JR that have potential clinical implications in transfusion and pregnancy settings. These include partial DIII type 4, weak D type 33, and Del RHD (IVS2-2delA). The rare Rh phenotypes D+ C+ E+ c- e+ and D+ C+ E+ c+ e- were also detected.DISCUSSION: The comprehensive analyses of blood group genetic variant profiles identified in this study will provide insight and an opportunity to improve Aboriginal health by aiding in the identification of appropriate blood products for population-specific transfusion needs.PMID:38557323 | DOI:10.2450/BloodTransfus.664

Source: Blood Transfusion - April 1, 2024 Category: Hematology Authors: Sudhir Jadhao Candice Davison Eileen Roulis Simon Lee Tamika Campbell Reece Griffin Maree Toombs Alex Brown Maree Perry Bushra Nasir David O Irving Catherine A Hyland Robert L Flower Shivashankar H Nagaraj Source Type: research