Neuronal control of microglia through the mitochondria

This study provides evidence that neurons may trigger microglia activation and subsequent neuroinflammation. In addition, we demonstrate that microglial activation may have a protective role in ameliorating neuronal innate immune activation, at least in the initial phase. This work challenges the current understanding of neuroinflammation by assigning the primary role to neurons.PMID:38626829 | DOI:10.1016/j.bbadis.2024.167167

Source: Biochimica et Biophysica Acta - April 16, 2024 Category: Biochemistry Authors: A R Pereira-Santos Emanuel Candeias J D Magalh ães Nuno Empadinhas A Raquel Esteves Sandra M Cardoso Source Type: research