Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device

Chem Commun (Camb). 2024 Apr 17. doi: 10.1039/d4cc00396a. Online ahead of print.ABSTRACTA heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach, where heart function-related HL-1 and HUVEC cells were arranged in separate compartments. Finally, the mechanism of aconitine-induced heart toxicity was elucidated using mass spectrometry and molecular biotechnology.PMID:38629248 | DOI:10.1039/d4cc00396a

Source: Chemical Communications - April 17, 2024 Category: Chemistry Authors: Tong Xu Zengnan Wu Hongren Yao Yingrui Zhang Shiyu Chen Yuxuan Li Xian-Li Meng Yi Zhang Jin-Ming Lin Source Type: research