Deep lymph node enlargement and renal failure caused by hypercalcemia ‑associated sarcoidosis: A case report

Exp Ther Med. 2024 Mar 27;27(5):235. doi: 10.3892/etm.2024.12524. eCollection 2024 May.ABSTRACTSarcoidosis is a rare disease that severely affects the lungs and superficial lymph nodes. In addition, this disease can also affect the skin, eyes and kidneys to varying degrees. The present report described a 32-year-old male patient who was admitted to Renmin Hospital of Wuhan University (Wuhan, China) due to joint pain in the extremities. He was diagnosed with uncorrectable hypercalcemia. A lymph node biopsy revealed the hypercalcemia to be associated with sarcoidosis, with the patient also demonstrating renal failure and lymph node enlargement. Administration of glucocorticoids provided benefits in terms of both primary and recurrent sarcoidosis, which also improved and preserved renal function. After being prescribed with oral prednisone treatment, blood calcium levels returned to normal, which indicated markedly improving renal function. However, the discontinuation of glucocorticoids for 2 months resulted in increased serum calcium and creatinine levels, both of which returned to abnormal levels. Overall, the present case report suggests that clinicians should actively perform sarcoidosis treatment in clinical practice to overcome any unexpected results associated with organ damage.PMID:38628656 | PMC:PMC11019652 | DOI:10.3892/etm.2024.12524
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research