Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU
Int J Hyg Environ Health. 2024 Apr 16;259:114378. doi: 10.1016/j.ijheh.2024.114378. Online ahead of print.ABSTRACTPhthalates and the substitute plasticizer DINCH belong to the first group of priority substances investigated by the European Human Biomonitoring Initiative (HBM4EU) to answer policy-relevant questions and safeguard an efficient science-to-policy transfer of results. Human internal exposure levels were assessed using two data sets from all European regions and Israel. The first collated existing human biomonitoring (HBM) data (2005-2019). The second consisted of new data generated in the harmonized "HBM4EU Aligned Studies" (2014-2021) on children and teenagers for the ten most relevant phthalates and DINCH, accompanied by a quality assurance/quality control (QA/QC) program for 17 urinary exposure biomarkers. Exposures differed between countries, European regions, age groups and educational levels. Toxicologically derived Human biomonitoring guidance values (HBM-GVs) were exceeded in up to 5% of the participants of the HBM4EU Aligned Studies. A mixture risk assessment (MRA) including five reprotoxic phthalates (DEHP, DnBP, DiBP, BBzP, DiNP) revealed that for about 17% of the children and teenagers, health risks cannot be excluded. Concern about male reproductive health emphasized the need to include other anti-androgenic substances for MRA. Contaminated food and the use of personal care products were identified as relevant exposure determinants paving the way for n...
Source: International Journal of Hygiene and Environmental health - Category: Environmental Health Authors: Antje Gerofke Rosa Lange Nina Vogel Phillipp Schmidt Till Weber Madlen David Hanne Frederiksen Kirsten Baken Eva Govarts Liese Gilles Laura Rodriguez Martin Žanna Martinsone Tiina Santonen Greet Schoeters Martin Scheringer Elena Dom ínguez-Romero Marta Source Type: research
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