The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial

CONCLUSIONS: The study findings indicate a relationship between aversive reinforcement learning mechanisms and aspects of depression, anxiety, and SSRI treatment, but these relationships did not align with the initial hypotheses. Poor task performance limits the interpretability and likely generalizability of the findings, and highlights the critical importance of developing acceptable and reliable tasks for use in clinical studies.FUNDING: This article presents research supported by NIHR Program Grants for Applied Research (RP-PG-0610-10048), the NIHR BRC, and UCL, with additional support from IMPRS COMP2PSYCH (JM, QH) and a Wellcome Trust grant (QH).PMID:38629200 | DOI:10.1017/S0033291724000837

Source: Psychological Medicine - April 17, 2024 Category: Psychiatry Authors: Jolanda Malamud Gemma Lewis Michael Moutoussis Larisa Duffy Jessica Bone Ramya Srinivasan Glyn Lewis Quentin J M Huys Source Type: research