Mechanistic insights into the conformational changes and alterations in residual communications due to the mutations in the pncA Gene of Mycobacterium tuberculosis: A computational perspective for effective therapeutic solutions

This study advances our knowledge of the primary cause of the mechanism of PZA resistance and the structural dynamics of pncA mutants, which will help us to design new and potent chemical scaffolds to treat drug-resistant TB (DR-TB).PMID:38615420 | DOI:10.1016/j.compbiolchem.2024.108065
Source: Computational Biology and Chemistry - Category: Bioinformatics Authors: Source Type: research