Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population

In conclusion, downregulation of survivin in the fibrotic liver decreases HSC activation by inducing cellular senescence and modulating macrophage cytokine expression that collectively ameliorates liver fibrosis.PMID:38545255 | PMC:PMC10964939 | DOI:10.1002/ccs3.12015

Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Sachin Sharma Shaikh Maryam Ghufran Mehreen Aftab Chhagan Bihari Sampa Ghose Subhrajit Biswas Source Type: research