Inhibition of the mPTP and Lipid Peroxidation Is Additively Protective Against I/R Injury

CONCLUSIONS: In the present study, we have investigated the relationship between Ca2+ and ROS, and how they individually or synergistically induce mitochondrial swelling. Our findings suggest that Ca2+ mediates mitochondrial damage through the opening of the mPTP, although ROS mediates its damaging effects through lipid peroxidation. However, subtoxic levels both Ca2+ and ROS can induce mPTP-mediated mitochondrial damage. Targeting both of these triggers to preserve mitochondria viability unveils a highly effective therapeutic approach for mitigating I/R injury.PMID:38618716 | DOI:10.1161/CIRCRESAHA.123.323882
Source: Circulation Research - Category: Cardiology Authors: Source Type: research