Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions

In this study, we show that human MAIT cells require exogenous iron, transported via CD71 for optimal metabolic activity in MAIT cells, including their production of ATP. We demonstrate that restricting iron availability by either chelating environmental iron or blocking CD71 on MAIT cells results in impaired cytokine production and proliferation. These data collectively highlight the importance of a CD71-iron axis for human MAIT cell metabolism and functionality, an axis that may have implications in conditions where iron availability is limited.PMID:38619286 | DOI:10.4049/jimmunol.2300649

Source: Journal of Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Eimear K Ryan Christy Clutter Conor De Barra Benjamin J Jenkins Simon O'Shaughnessy Odhr án K Ryan Chloe McKenna Helen M Heneghan Fiona Walsh David K Finlay Linda V Sinclair Nicholas Jones Daniel T Leung Donal O'Shea Andrew E Hogan Source Type: research