Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results

DISCUSSION: Cerebral perfusion is a potential biomarker for assessing genetic FTD and its genetic subgroups prior to symptom onset.HIGHLIGHTS: Gray matter perfusion declines in at-risk genetic frontotemporal dementia (FTD). Regional perfusion decline differs between at-risk genetic FTD subgroups . Hypoperfusion in the left thalamus is common across all presymptomatic groups. Converters exhibit greater right frontal hypoperfusion than non-converters past their expected conversion date. Cerebral hypoperfusion is a potential early biomarker of genetic FTD.PMID:38623902 | DOI:10.1002/alz.13750

Source: The Journal of Alzheimers Association - April 16, 2024 Category: Psychiatry Authors: Maurice Pasternak Saira S Mirza Nicholas Luciw Henri J M M Mutsaerts Jan Petr David Thomas David Cash Martina Bocchetta Maria Carmela Tartaglia Sara B Mitchell Sandra E Black Morris Freedman David Tang-Wai Ekaterina Rogaeva Lucy L Russell Arabella Bouzigu Source Type: research