Auditory mismatch negativity in pre-manifest and manifest Huntington's disease

CONCLUSION: These results suggest an initial and subtle deterioration of pre-attentive mechanisms in the presymptomatic phase of HD, with an increasing phase shift in the MMN time frame. This result could indicate initial functional changes with a possible compensatory effect.SIGNIFICANCE: An initial and slight decrease in MMN associated with increased phase coherence in the corresponding EEG frequencies could indicate an early functional involvement of pre-attentive resources that could precede the clinical expression of HD.PMID:38603947 | DOI:10.1016/j.clinph.2024.03.020

Source: Clinical Neurophysiology - April 11, 2024 Category: Neurology Authors: Marianna Delussi Christian Valt Adelchi Silvestri Katia Ricci Emanuella Ladisa Elena Ammendola Antonio Rampino Giulio Pergola Marina de Tommaso Source Type: research